C3 Glomerulonephritis Associated with Monoclonal Gammopathy of Renal Significance

Introduction: Monoclonal gammopathy of renal significance (MGRS) is described as a hematologic condition characterized by nephrotoxicmonoclonal proteins produced non-malignant B-cell or plasma cell clone. Nevertheless, MGRS can cause serious lesions, leading to high morbidity. In C3 glomerulonephritis, monoclonal protein damage indirectly. Acting an autoantibody, the cannot be detected in kidney biopsy, promoting dysregulation alternative pathway complement system.Material and Methods: This non-systematic review was based on comprehensive search databases scientific journals, such PubMed, Nature Reviews Nephrology Kidney International, including terms ‘C3 Glomerulonephritis’ ‘Monoclonal significance’. We pathophysiology, presentation, diagnosis, differential diagnosis treatment glomerulonephritis associated with MGRS.Discussion: With increasing understanding complex interaction between damage, it becomes clear that early recognition crucial, Ig-directed therapy might improve outcomes. this context, order maximize chance correct biopsy mandatory determine exact nature lesion, severity disease. Conclusion: It important make MGRS-associated prevent not only progression hematological malignancy, but also end-stage